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KMID : 0032220200320020164
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Annals of Dermatology
2020 Volume.32 No. 2 p.164 ~ p.167
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A Case of Cutaneous Leukocytoclastic Vasculitis Associated with Granulocyte Colony-Stimulating Factor: An Unusual Presentation
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Yoon Do-Kyoung
Byun Hyun-Jeong
Oh Se-Jin
Park Ji-Hye
Lee Dong-Youn
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Abstract
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Drug-induced vasculitis is an inflammation of small-sized blood vessel caused by the use of drugs. It accounts for approximately 10% of acute cutaneous vasculitis. Propylthiouracil, hydralazine, and allopurinol have been widely known as causative agents. The most common clinical feature of drug-induced vasculitis is palpable purpura on lower extremities. A 66-year-old Korean female presented with erythematous nodules on upper chest and back. She had been on medication for multiple myeloma. Laboratory results showed neutropenia. After a single injection of filgrastim (recombinant granulocyte colony-stimulating factor), she developed cutaneous lesions with concurrent increase in absolute neutrophil count. A skin biopsy revealed leukocytoclastic vasculitis. After discontinuation of filgrastim injection, her skin lesions disappeared spontaneously.
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KEYWORD
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Cutaneous, Cutaneous small vessel, Granulocyte colonystimulating factor, Skin, Vasculitis
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